⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9359108 | 0.90 | — | — | |
| SCHEMBL9452035 | 0.88 | — | — | |
| SCHEMBL7103639 | 0.87 | — | — | |
| SCHEMBL9359388 | 0.87 | CA2 (0.34) | — | |
| SCHEMBL9139099 | 0.83 | GABRA1 (0.38) | — | |
| SCHEMBL9137804 | 0.82 | — | — | |
| SCHEMBL9136110 | 0.80 | — | — | |
| SCHEMBL9452038 | 0.79 | — | — | |
| SCHEMBL9136927 | 0.78 | — | — | |
| SCHEMBL7080977 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030134898-A1 | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production | HOMAN REYNOLD (US) | 2003-07-17 | — | — | US | claimed |
| EP-1281399-A2 | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production | WARNER-LAMBERT COMPANY (US) | 2003-02-05 | — | — | EP | claimed |
| US-20020183384-A1 | Methods of treating nuclear factor-kappa B mediated diseases and disorders | CORNICELLI JOSEPH ANTHONY (US) | 2002-12-05 | — | — | US | claimed |
| EP-1236468-A1 | Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| US-5384328-A | Anticholesterol agents | WARNER-LAMBERT COMPANY (US) | 1995-01-24 | — | — | US | claimed |
| EP-0555351-B1 | OXYSULFONYL CARBAMATES | WARNER LAMBERT CO (US) | 1994-12-28 | — | — | EP | claimed |
| WO-1992007826-A1 | OXYSULFONYL CARBAMATES | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | claimed |
| US-20030134898-A1 | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production | HOMAN REYNOLD (US) | 2003-07-17 | — | — | US | disclosed |
| EP-1281399-A2 | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production | WARNER-LAMBERT COMPANY (US) | 2003-02-05 | — | — | EP | disclosed |
| US-20020183384-A1 | Methods of treating nuclear factor-kappa B mediated diseases and disorders | CORNICELLI JOSEPH ANTHONY (US) | 2002-12-05 | — | — | US | disclosed |
| EP-1236468-A1 | Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| US-5384328-A | Anticholesterol agents | WARNER-LAMBERT COMPANY (US) | 1995-01-24 | — | — | US | disclosed |
| EP-0555351-B1 | OXYSULFONYL CARBAMATES | WARNER LAMBERT CO (US) | 1994-12-28 | — | — | EP | disclosed |
| US-5245068-A | Acylcoenzyme A cholesterol acyltransferase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| WO-1992007826-A1 | OXYSULFONYL CARBAMATES | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |