Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7109239 | 0.79 | HSD17B10 (0.41) | BCHEKDM4EMAPTPOLBPNP | |
| SCHEMBL7660927 | 0.78 | GRIN2D (0.42) | BCHESMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL7107256 | 0.77 | BCHE (0.43) | BCHESMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL7661306 | 0.74 | ALDH1A1 (0.46) | BCHESMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL7109245 | 0.74 | — | — | |
| SCHEMBL7104647 | 0.72 | PNP (0.32) | PNP | |
| SCHEMBL15483862 | 0.71 | GRIN2D (0.44) | BCHESMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL4268319 | 0.69 | PIM1 (0.35) | KDM4EPOLB | |
| SCHEMBL7650291 | 0.68 | POLB (0.42) | BCHESMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL7109379 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |