Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655280 | 0.80 | HSD17B10 (0.49) | HSD17B10POLBPDCD1CD274KDM4E | |
| SCHEMBL7108658 | 0.79 | BCHE (0.41) | POLBPNPMAPTBCHEKDM4E | |
| SCHEMBL7107855 | 0.79 | HSD17B10 (0.47) | HSD17B10POLBPDCD1CD274PNP | |
| SCHEMBL7662648 | 0.76 | HSD17B10 (0.41) | HSD17B10POLBLTA4H | |
| SCHEMBL7106657 | 0.76 | PNP (0.39) | PNP | |
| SCHEMBL7108601 | 0.74 | TYMP (0.39) | POLBPNPKDM4EL3MBTL1 | |
| SCHEMBL7103722 | 0.71 | — | — | |
| SCHEMBL7108544 | 0.71 | PNP (0.36) | PNP | |
| SCHEMBL7655038 | 0.71 | PDCD1 (0.44) | HSD17B10POLBPDCD1CD274MAPT | |
| SCHEMBL14665877 | 0.71 | HSD17B10 (0.44) | HSD17B10POLBPDCD1CD274MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |