SCHEMBL7109176

SCHEMBL7109176

CC(=O)[C@H](NC(=O)OCc1ccccc1)C(Cl)c1cccc2ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 6/20 0.54
ALDH1A1 P00352 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
HPGD P15428 1/20 0.45
CYP2C19 P33261 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CTSL P07711 3/20 0.45
CTSS P25774 3/20 0.45
ALOX15 P16050 1/20 0.45
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 1/20 0.44
CTSB P07858 2/20 0.43
ATM Q13315 1/20 0.43
CTSK P43235 1/20 0.43
PLAU P00749 1/20 0.43
TOP2A P11388 1/20 0.43
TOP2B Q02880 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6500768 0.83 CASP1 (0.56) CASP1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL6501321 0.83 CASP1 (0.56) CASP1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL13168669 0.81 CASP1 (0.56) CASP1ALDH1A1ALOX15LMNAATM
SCHEMBL29207429 0.81 CASP1 (0.63) CASP1LMNAATMTOP2ATOP2B
SCHEMBL10577245 0.80 CASP1 (0.54) CASP1CTSLCTSSPLAUCTRB1
SCHEMBL6487625 0.80 CASP1 (0.57) CASP1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL7141233 0.78 CASP1 (0.60) CASP1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL8346816 0.76 CTSL (0.62) CASP1ALDH1A1CTSLCTSSALOX15
SCHEMBL6436627 0.76 CTSL (0.62) CASP1ALDH1A1CTSLCTSSALOX15
SCHEMBL17704241 0.76 CTSL (0.62) CASP1ALDH1A1CTSLCTSSALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1346972-A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOHYDRIN COMPOUND Ajinomoto Co., Inc. (JP) 2003-09-24 EP disclosed