Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | MC4R | P32245 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | MC3R | P41968 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037984 | 0.91 | TSHR (0.54) | TSHRADORA3MC4RADRA1AMC3R | |
| SCHEMBL163537 | 0.85 | ADORA3 (0.48) | TSHRADORA3MC4RADRA1AMC3R | |
| SCHEMBL163536 | 0.85 | ADORA3 (0.48) | TSHRADORA3MC4RADRA1AMC3R | |
| SCHEMBL31555012 | 0.84 | SIRT6 (0.50) | TSHRADORA3MC4RADRA1AMC3R | |
| SCHEMBL19151399 | 0.84 | ADORA3 (0.47) | TSHRADORA3MC4RADRA1AMC3R | |
| SCHEMBL6377563 | 0.84 | ADORA3 (0.47) | TSHRADORA3MC4RADRA1AMC3R | |
| SCHEMBL3743154 | 0.84 | ADORA3 (0.47) | TSHRADORA3MC4RADRA1AMC3R | |
| SCHEMBL13837305 | 0.84 | ADORA3 (0.47) | TSHRADORA3MC4RADRA1AMC3R | |
| SCHEMBL741061 | 0.84 | SIRT6 (0.50) | TSHRADORA3MC4RADRA1AMC3R | |
| Hydrochloric Acid SCHEMBL21752450 | 0.82 | ADORA3 (0.45) | TSHRADORA3MC4RADRA1AMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| EP-1001944-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999003844-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | claimed |