SCHEMBL7109657

Cc1cccc(-c2ccccc2CCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C)c2ccncc2)C(C)(C)C)[C@@H]2OC(C)(C)OC2=O)c1

nearest known ligand 0.41

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	MMP2	P08253	20/20	0.41

▸	MMP3	P08254	10/20	0.41

▸	MMP1	P03956	1/20	0.39

▸	BMP1	P13497	1/20	0.39

▸	MMP9	P14780	1/20	0.39

▸	MMP13	P45452	1/20	0.39

▸	MMP14	P50281	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7701844	0.94	MMP2 (0.46)	MMP2MMP3MMP1BMP1MMP9
SCHEMBL7108065	0.94	MMP2 (0.46)	MMP2MMP3MMP1BMP1MMP9
SCHEMBL7111450	0.93	MMP2 (0.40)	MMP2MMP3MMP1BMP1MMP9
SCHEMBL7110097	0.87	MMP2 (0.35)	MMP2MMP3MMP1BMP1MMP9
SCHEMBL7112575	0.86	MMP2 (0.40)	MMP2MMP3MMP1BMP1MMP9
SCHEMBL7116159	0.85	MMP2 (0.48)	MMP2MMP3MMP1MMP9MMP13
SCHEMBL7109651	0.84	MMP2 (0.57)	MMP2MMP3MMP1BMP1MMP9
SCHEMBL7109653	0.84	MMP2 (0.46)	MMP2MMP3MMP1BMP1MMP9
SCHEMBL7110247	0.81	LMNA (0.35)	MMP2MMP3
Hydrochloric Acid SCHEMBL7111455	0.80	MMP2 (0.58)	MMP2MMP3MMP1BMP1MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1047665-B1	MATRIX METALLOPROTEASE INHIBITORS	PFIZER LTD (GB)	2003-10-22	—	—	EP	disclosed
US-6350907-B1	PEPTIDE ENZYME INHIBITORS	PFIZER INC	2002-02-26	—	—	US	disclosed