Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106226 | 0.87 | TP53 (0.48) | TP53MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL7109682 | 0.85 | MAPT (0.61) | TP53MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL7109998 | 0.79 | TP53 (0.75) | TP53MAPTRAB9AKDM4ENPC1 | |
| Ammonia Solution, Strong SCHEMBL7106619 | 0.78 | TP53 (0.73) | TP53MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL7106230 | 0.75 | MAPT (0.47) | TP53MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL7105715 | 0.72 | MAPT (0.57) | TP53MAPTRAB9AKDM4EMEN1 | |
| SCHEMBL22052874 | 0.72 | KDM4E (0.64) | TP53MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL27183130 | 0.70 | ACP1 (0.64) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL31482694 | 0.69 | MAPT (0.72) | TP53MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL13857587 | 0.69 | MAPT (0.67) | TP53MAPTRAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812319-B9 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2003-10-08 | — | — | EP | claimed |
| EP-0812319-B1 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2002-07-10 | — | — | EP | claimed |