Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.75 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | APP | P05067 | 3/20 | 0.62 |
| ▸ | GLA | P06280 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MMP9 | P14780 | 2/20 | 0.60 |
| ▸ | MMP8 | P22894 | 2/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL7106619 | 0.99 | TP53 (0.73) | TP53GAAAPPGLAMEN1 | |
| SCHEMBL7109439 | 0.84 | TP53 (0.73) | TP53GAAAPPGLAMEN1 | |
| SCHEMBL7258969 | 0.81 | MAPT (0.74) | TP53GAAAPPGLAMEN1 | |
| SCHEMBL4780914 | 0.80 | APP (0.77) | TP53GAAAPPGLAMEN1 | |
| SCHEMBL24155562 | 0.80 | APP (0.76) | TP53GAAAPPGLAMEN1 | |
| SCHEMBL8397393 | 0.80 | APP (0.76) | TP53GAAAPPGLAMEN1 | |
| SCHEMBL366824 | 0.79 | RAB9A (0.81) | TP53GAAAPPGLAMEN1 | |
| SCHEMBL29474819 | 0.79 | RAB9A (0.81) | TP53GAAAPPGLAMEN1 | |
| SCHEMBL7109795 | 0.79 | TP53 (0.49) | TP53MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL3679894 | 0.79 | ALDH1A1 (0.78) | TP53GAAAPPGLAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812319-B9 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2003-10-08 | — | — | EP | claimed |
| EP-0812319-B1 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2002-07-10 | — | — | EP | claimed |