Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.55 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
| ▸ | FABP1 | P07148 | 1/20 | 0.46 |
| ▸ | FABP6 | P51161 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168145 | 0.88 | KDM5B (0.66) | KDRKDM5BKDM4EMAPTMEN1 | |
| SCHEMBL18070922 | 0.87 | KDM4E (0.62) | KDRKDM4EMAPTMEN1KMT2A | |
| SCHEMBL20722727 | 0.85 | KDM4E (0.62) | KDRKDM5BKDM4EMAPTMEN1 | |
| SCHEMBL5871444 | 0.82 | PKM (0.58) | KDRKDM5BKDM4EMAPTMEN1 | |
| SCHEMBL8338005 | 0.81 | KDR (0.51) | KDRKDM5BKDM4EMAPTMEN1 | |
| SCHEMBL1715912 | 0.79 | KDR (0.64) | KDRKDM5BKDM4EMAPTMEN1 | |
| SCHEMBL31362674 | 0.79 | KDR (0.69) | KDRKDM4EMAPTMEN1KMT2A | |
| SCHEMBL2087990 | 0.79 | HTT (0.65) | KDRKDM4EMAPTMEN1LMNA | |
| SCHEMBL15528935 | 0.79 | KDR (0.84) | KDRKDM4EMAPTMEN1LMNA | |
| SCHEMBL8298604 | 0.79 | KDR (0.60) | KDRKDM4EMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054868-B1 | SUBSTITUTED PYRIDINO ARYLPIPERAZINES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | ORTHO MCNEIL PHARM INC (US) | 2003-09-24 | — | — | EP | disclosed |
| US-6218396-B1 | SELECTIVELY INHIBITS BINDING TO AN ADRENERGIC RECEPTOR | ORTH-MCNEIL PHARMACEUTICAL, INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1054868-A1 | NOVEL SUBSTITUTED PYRIDINO ARYLPIPERAZINES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999042448-A1 | NOVEL SUBSTITUTED PYRIDINO ARYLPIPERAZINES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-08-26 | — | — | WO | disclosed |