Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104690 | 0.86 | CNR1 (0.30) | CNR1 | |
| SCHEMBL7104663 | 0.85 | CNR1 (0.32) | CNR1 | |
| SCHEMBL7651990 | 0.84 | ROCK2 (0.39) | PDE10AROCK2ROCK1LMNANTRK1 | |
| SCHEMBL7106490 | 0.83 | MEN1 (0.36) | PDE10AROCK2ROCK1AKR1C3LMNA | |
| SCHEMBL7107198 | 0.83 | — | — | |
| SCHEMBL7659400 | 0.81 | AKR1C3 (0.39) | PDE10AROCK2ROCK1AKR1C3LMNA | |
| SCHEMBL7654097 | 0.78 | — | — | |
| SCHEMBL7107359 | 0.76 | HDAC4 (0.39) | PDE10ACNR1 | |
| SCHEMBL24342211 | 0.76 | TDP1 (0.39) | PDE10AROCK2ROCK1LMNANTRK1 | |
| SCHEMBL7658471 | 0.76 | ROCK2 (0.39) | PDE10AROCK2ROCK1AKR1C3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |