Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662443 | 0.86 | KMT2A (0.36) | AKR1C3ROCK2ROCK1KMT2AMEN1 | |
| SCHEMBL7654546 | 0.85 | KMT2A (0.38) | AKR1C3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7656151 | 0.83 | CASP3 (0.34) | KMT2AMEN1KDM4EALDH1A1CYP2C9 | |
| SCHEMBL7109867 | 0.81 | PDE10A (0.36) | AKR1C3ROCK2ROCK1PDE10ALMNA | |
| SCHEMBL7654556 | 0.78 | KMT2A (0.35) | KMT2AMEN1KDM4EALDH1A1CYP2C9 | |
| SCHEMBL7106490 | 0.77 | MEN1 (0.36) | AKR1C3ROCK2ROCK1KMT2AMEN1 | |
| SCHEMBL7662074 | 0.76 | KMT2A (0.45) | AKR1C3KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7658471 | 0.76 | ROCK2 (0.39) | AKR1C3ROCK2ROCK1KMT2AKDM4E | |
| SCHEMBL7651968 | 0.75 | KDM4E (0.40) | ROCK2ROCK1KMT2AMEN1KDM4E | |
| SCHEMBL7654547 | 0.73 | KMT2A (0.36) | KMT2AMEN1KDM4EALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |