Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | DGKA | P23743 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31137801 | 0.97 | ADRB2 (0.45) | ADRB2ADRB1ADRB3ALDH1A1ATM | |
| Fluoride Ion SCHEMBL7113604 | 0.94 | ADRB2 (0.43) | ADRB2ADRB1ADRB3ALDH1A1ATM | |
| Iodide SCHEMBL9485433 | 0.94 | ADRB2 (0.43) | ADRB2ADRB1ADRB3ALDH1A1ATM | |
| Hydrochloric Acid SCHEMBL234590 | 0.94 | ADRB2 (0.43) | ADRB2ADRB1ADRB3ALDH1A1ATM | |
| SCHEMBL11052429 | 0.94 | ADRB2 (0.43) | ADRB2ADRB1ADRB3ALDH1A1ATM | |
| Bromide SCHEMBL5181055 | 0.88 | TSHR (0.44) | TSHRCA1CA2CA12CA9 | |
| Hydrochloric Acid SCHEMBL11127961 | 0.85 | CA1 (0.42) | TSHRCA1CA2CA12CA9 | |
| Hydrochloric Acid SCHEMBL10581327 | 0.82 | TSHR (0.45) | TSHRCA1CA2CA12CA9 | |
| Hydrochloric Acid SCHEMBL8190290 | 0.82 | TSHR (0.45) | TSHRCA1CA2CA12CA9 | |
| Hydrochloric Acid SCHEMBL9709576 | 0.82 | TSHR (0.45) | TSHRCA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0834514-B1 | Process for synthesizing metallocene compounds | KANTO KAGAKU (JP) | 2003-10-22 | — | — | EP | disclosed |
| US-6268443-B1 | ORGANO ALUMINUM COMPOUNDS AND CATALYSTS FOR POLYMERS AND COPOLYMERS, SPRAYING MIXTURES OF MAGNESIUM CHLORIDE WITH ALCOHOLS AND TITANIUM HALIDES | CHISSO CORPORATION (JP) | 2001-07-31 | — | — | US | disclosed |
| US-6020279-A | COORDINATION CATALYST | CHISSO CORPORATION (JP) | 2000-02-01 | — | — | US | disclosed |
| EP-0700936-B1 | A process for producing a solid catalyst component for olefin polymerization and a process for producing an olefin polymer | CHISSO CORP (JP) | 1998-11-04 | — | — | EP | disclosed |
| EP-0604401-B1 | Production of a catalyst component for producing crystalline polymers | CHISSO CORP (JP) | 1997-09-24 | — | — | EP | disclosed |
| EP-0700936-A1 | A process for producing a solid catalyst component for olefin polymerization and a process for producing an olefin polymer | CHISSO CORPORATION (JP) | 1996-03-13 | — | — | EP | disclosed |
| EP-0604401-A2 | Production of a catalyst component for producing crystalline polymers | CHISSO CORPORATION (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5173540-A | Coordination catalyst comprising titanium compound, organo aluminum compound electron donor and a polymer support; transparent, voidless films produced | CHISSO CORPORATION (JP) | 1992-12-22 | — | — | US | disclosed |
| EP-0395391-A2 | Catalyst component for producing crystalline polymers and a process for producing the catalyst | CHISSO CORPORATION (JP) | 1990-10-31 | — | — | EP | disclosed |
| US-4831091-A | USING A COORDINATION CATALYST CONTAINING A SILANETRIOL OR -DIOL AS WELL AS AN AROMATIC ESTSER; ODORLESS; STEREOSPECIFIC; PARTICLE SIZES | CHISSO CORPORATION (JP) | 1989-05-16 | — | — | US | disclosed |
| EP-0072035-B1 | PROCESS FOR PRODUCING POLYOLEFINS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-02-19 | — | — | EP | disclosed |
| US-4551439-A | Solid catalyst component for olefin polymerization and process for producing same | CHISSO CORPORATION (JP) | 1985-11-05 | — | — | US | disclosed |
| US-4483939-A | USING COORDINATION CATALYST OF TITANIUM AND/OR VANADIUM COMPOUND, PHENOL, AROMATIC ESTER, ORGANOMAGNESIUM AND ORGANOALUMINUM COMPOUNDS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-11-20 | — | — | US | disclosed |
| US-4394292-A | MAGNESIUM COMPOUND, PHOSPHORUS COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-07-19 | — | — | US | disclosed |
| EP-0072035-A2 | Process for producing polyolefins | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-02-16 | — | — | EP | disclosed |
| US-4347157-A | TITANIUM AND/OR VANADIUM SOLID COMPOUND ON SUPPORT | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-08-31 | — | — | US | disclosed |