Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.34 |
| ▸ | DHODH | Q02127 | 4/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7109230 | 0.89 | POLB (0.38) | DHODHNOTUMCHRM5 | |
| SCHEMBL6725969 | 0.83 | PTGES2 (0.38) | DYRK1APDE10ADHODHCHRM5PIM1 | |
| SCHEMBL6725490 | 0.83 | PIM1 (0.35) | DYRK1APDE10ADHODHCHRM5PIM1 | |
| SCHEMBL7111728 | 0.82 | SCN5A (0.35) | — | |
| SCHEMBL6729851 | 0.81 | PTGES2 (0.35) | DYRK1APDE10ADHODHLDHANOTUM | |
| SCHEMBL7115763 | 0.77 | ALKBH5 (0.36) | NOTUM | |
| SCHEMBL7111700 | 0.77 | KAT2B (0.31) | — | |
| SCHEMBL7115556 | 0.76 | NPC1 (0.36) | — | |
| SCHEMBL7114074 | 0.76 | PIK3CA (0.32) | PDE4BPDE4D | |
| SCHEMBL7110053 | 0.73 | PTGS2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |