Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607788 | 0.80 | MAPT (0.62) | KMT2AMEN1RXFP1CETPHDAC3 | |
| SCHEMBL30136216 | 0.80 | MAPT (0.62) | KMT2AMEN1RXFP1CETPHDAC3 | |
| SCHEMBL2893938 | 0.76 | GAA (0.52) | KMT2ACETPHDAC3HDAC1HDAC2 | |
| SCHEMBL7113819 | 0.75 | MAPT (0.37) | KMT2AMEN1GAAMAPTSMN1; SMN2 | |
| SCHEMBL7107830 | 0.73 | ALDH1A1 (0.44) | KMT2AMEN1TSHRMAPTSMN1; SMN2 | |
| SCHEMBL687471 | 0.72 | POLB (0.47) | KMT2AMEN1TSHRHDAC3HDAC1 | |
| SCHEMBL2893787 | 0.71 | KMT2A (0.50) | KMT2AMEN1TSHRCETPHDAC3 | |
| SCHEMBL5217967 | 0.71 | KMT2A (0.42) | KMT2AMEN1GAAHPGDMAPT | |
| SCHEMBL693169 | 0.71 | PTPN1 (0.69) | KMT2AMEN1PTPN1HPGDMAPT | |
| SCHEMBL2903210 | 0.71 | SMN1; SMN2 (0.64) | KMT2AMEN1TSHRRXFP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351924-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Pharma Company (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002050019-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB PHARMA CO. (US) | 2002-06-27 | — | — | WO | disclosed |