Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 10/20 | 0.43 |
| ▸ | GSK3A | P49840 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4892709 | 0.87 | RAB9A (0.50) | AURKAMEN1MAPTKMT2A | |
| SCHEMBL7112335 | 0.84 | GSK3B (0.46) | GSK3BTOP2ABRAFAURKAGSK3A | |
| SCHEMBL7108322 | 0.76 | GSK3B (0.50) | GSK3BTOP2ABRAFAURKAGSK3A | |
| SCHEMBL7107687 | 0.76 | ALK (0.57) | AURKACHEK1NTRK2MEN1MAPT | |
| SCHEMBL459413 | 0.74 | IGF1R (0.51) | GSK3BAURKAGSK3AJAK2AURKB | |
| SCHEMBL7110570 | 0.73 | POLB (0.55) | GSK3BTOP2ABRAFAURKAGSK3A | |
| SCHEMBL7106217 | 0.73 | GSK3B (0.53) | GSK3BAURKAGSK3APIN1MEN1 | |
| SCHEMBL7106210 | 0.73 | GSK3B (0.53) | GSK3BAURKAGSK3APIN1MEN1 | |
| SCHEMBL7104854 | 0.72 | SMN1; SMN2 (0.56) | BRAFMEN1MAPTKMT2A | |
| SCHEMBL7105790 | 0.72 | MERTK (0.53) | GSK3BTOP2ABRAFPIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | claimed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | claimed |
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | disclosed |