Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726385 | 0.91 | PTGS2 (0.46) | PTGS2MEN1NPC1KMT2AATM | |
| SCHEMBL6723146 | 0.90 | PTGS2 (0.45) | PTGS2MEN1NPC1KMT2AATM | |
| SCHEMBL6726445 | 0.85 | MEN1 (0.40) | PTGS2MEN1NPC1KMT2AATM | |
| SCHEMBL6739896 | 0.84 | PTGS2 (0.46) | PTGS2MEN1NPC1KMT2AATM | |
| SCHEMBL6730008 | 0.84 | PTGS2 (0.44) | PTGS2MEN1NPC1KMT2AATM | |
| SCHEMBL6741063 | 0.83 | PTGS2 (0.46) | PTGS2MEN1NPC1KMT2AATM | |
| SCHEMBL6722256 | 0.83 | PTGS2 (0.46) | PTGS2MEN1NPC1KMT2AATM | |
| SCHEMBL7108676 | 0.83 | PTGS2 (0.47) | PTGS2NPC1KMT2APTGS1 | |
| SCHEMBL6730299 | 0.83 | PTGS2 (0.46) | PTGS2PAX8PTGS1CA4 | |
| SCHEMBL6733458 | 0.82 | PTGS2 (0.42) | PTGS2MEN1NPC1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |