Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721984 | 0.91 | PTGS2 (0.46) | PTGS2PTGS1HTR7RAB9AKMT2A | |
| SCHEMBL6722666 | 0.91 | PTGS2 (0.54) | PTGS2PTGS1HTR7RAB9APOLB | |
| SCHEMBL7116583 | 0.90 | PTGS2 (0.47) | PTGS2PTGS1HTR7GPBAR1ALDH1A1 | |
| SCHEMBL7110302 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL7115127 | 0.84 | PTGS2 (0.42) | PTGS2PTGS1KMT2AALDH1A1NPC1 | |
| SCHEMBL6722694 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1HTR7RAB9AALDH1A1 | |
| SCHEMBL6722945 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1GPBAR1RAB9AKMT2A | |
| SCHEMBL7112894 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1KMT2ANPC1 | |
| SCHEMBL6735331 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1HTR7GSRGPBAR1 | |
| SCHEMBL6734771 | 0.82 | PTGS2 (0.45) | PTGS2PTGS1HTR7GPBAR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |