Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113934 | 0.76 | TSHR (0.50) | CYP19A1ALDH1A1 | |
| SCHEMBL30583096 | 0.70 | MAOB (0.62) | MAOBMAOACYP19A1CA1CA2 | |
| SCHEMBL49433 | 0.70 | MAOB (0.62) | MAOBMAOACYP19A1CA1CA2 | |
| Hydrochloric Acid SCHEMBL10936113 | 0.68 | MAOB (0.64) | MAOBMAOACYP19A1CA1CA2 | |
| SCHEMBL9719335 | 0.68 | MAOB (0.60) | MAOBMAOACYP19A1CA1CA2 | |
| Hydrochloric Acid SCHEMBL8644377 | 0.68 | MAOB (0.64) | MAOBMAOACYP19A1CA1CA2 | |
| SCHEMBL7115400 | 0.67 | MRGPRX4 (0.63) | MRGPRX4MAOBMAOA | |
| SCHEMBL9719373 | 0.66 | CA1 (0.62) | MAOBMAOACYP19A1CA1CA2 | |
| SCHEMBL30324526 | 0.66 | CA1 (0.62) | MAOBMAOACYP19A1CA1CA2 | |
| SCHEMBL3482569 | 0.66 | CA1 (0.62) | MAOBMAOACYP19A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030203908-A1 | Dihydrofolate reductase inhibitors | ISIS INNOVATION LIMITED (GB) | 2003-10-30 | — | — | US | disclosed |
| WO-2001053276-A1 | DIHYDROFOLATE REDUCTASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2001-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203908-A1 | Dihydrofolate reductase inhibitors | DHFR, CBR1, GRHPR | MRGPRX4 2858/4885MAOB 85/4885MAOA 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.