Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114179 | 0.89 | PTGS1 (0.50) | PTGS1PTGS2CYP3A4TSHRCYP1A2 | |
| SCHEMBL28758420 | 0.85 | CYP3A4 (0.38) | PTGS1PTGS2SYNJ2CYP3A4TSHR | |
| SCHEMBL8498059 | 0.81 | THRB (0.49) | PTGS1PTGS2LMNAMEN1KMT2A | |
| SCHEMBL11578757 | 0.78 | ALDH1A1 (0.69) | PTGS1PTGS2CYP3A4TSHRCYP1A2 | |
| SCHEMBL11813291 | 0.77 | PTGS1 (0.60) | PTGS1PTGS2CYP3A4TSHRCYP1A2 | |
| SCHEMBL4695867 | 0.77 | CA12 (0.65) | PTGS1PTGS2CYP3A4TSHRCYP1A2 | |
| SCHEMBL1105482 | 0.77 | ALDH1A1 (0.51) | PTGS1PTGS2CYP3A4TSHRCYP1A2 | |
| SCHEMBL10239573 | 0.75 | MAPT (0.58) | PTGS1PTGS2CYP3A4TSHRCYP1A2 | |
| SCHEMBL7436393 | 0.75 | PTGS1 (0.50) | PTGS1PTGS2CYP3A4TSHRCYP1A2 | |
| SCHEMBL18090937 | 0.75 | MAPK1 (0.59) | PTGS1PTGS2CYP3A4TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991618-B1 | SELECTIVE THYROID HORMONE ANALOGS | UNIV CALIFORNIA (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-0991618-A4 | SELECTIVE THYROID HORMONE ANALOGS | UNIV CALIFORNIA (US) | 2000-09-27 | — | — | EP | disclosed |
| EP-0991618-A1 | SELECTIVE THYROID HORMONE ANALOGS | The Regents of the University of California (US) | 2000-04-12 | — | — | EP | disclosed |
| US-5883294-A | THYROID HORMONE AGONIST | THE REGEANTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-03-16 | — | — | US | disclosed |
| WO-1998057919-A1 | SELECTIVE THYROID HORMONE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-23 | — | — | WO | disclosed |