Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.72 |
| ▸ | MEN1 | O00255 | 8/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.72 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.68 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.68 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | TP53 | P04637 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | TNKS | O95271 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120599 | 0.91 | AKR1C3 (0.66) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL4649397 | 0.86 | AR (0.72) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL312467 | 0.85 | ALDH1A1 (0.65) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL7127255 | 0.85 | KDM4E (0.73) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL4650047 | 0.84 | HPGD (1.00) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL30089725 | 0.84 | AR (0.72) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL22806289 | 0.83 | ALDH1A1 (0.65) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL2398219 | 0.82 | KDM4E (0.66) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL15676335 | 0.82 | HPGD (0.74) | HPGDCYP3A4KDM4ECYP2C19MEN1 | |
| SCHEMBL312354 | 0.81 | ALDH1A1 (0.75) | HPGDCYP3A4KDM4ECYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504327-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | claimed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | claimed |
| US-6555523-B1 | Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus | CASCADE ESTATES LTD. (MU) | 2003-04-29 | — | — | US | disclosed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | disclosed |