Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.66 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.66 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.65 |
| ▸ | HPGD | P15428 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 8/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | TNKS | O95271 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121068 | 0.91 | HPGD (0.72) | AKR1C3AKR1C2AKR1C1KDM4ECYP3A4 | |
| SCHEMBL30089725 | 0.85 | AR (0.72) | KDM4ECYP3A4HPGDMAPTALDH1A1 | |
| SCHEMBL22806289 | 0.84 | ALDH1A1 (0.65) | AKR1C3AKR1C2AKR1C1KDM4ECYP3A4 | |
| SCHEMBL7127255 | 0.84 | KDM4E (0.73) | AKR1C3AKR1C2AKR1C1KDM4ECYP3A4 | |
| SCHEMBL12830223 | 0.83 | MEN1 (0.72) | KDM4ECYP3A4HPGDMAPTALDH1A1 | |
| SCHEMBL4649397 | 0.83 | AR (0.72) | KDM4ECYP3A4HPGDMAPTALDH1A1 | |
| SCHEMBL29370223 | 0.82 | HPGD (0.81) | AKR1C3AKR1C2AKR1C1KDM4ECYP3A4 | |
| SCHEMBL16670860 | 0.82 | HPGD (0.81) | AKR1C3AKR1C2AKR1C1KDM4ECYP3A4 | |
| SCHEMBL312467 | 0.82 | ALDH1A1 (0.65) | AKR1C3AKR1C2AKR1C1KDM4ECYP3A4 | |
| SCHEMBL8934553 | 0.81 | GABRP (0.64) | KDM4ECYP3A4HPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504327-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | claimed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | claimed |
| US-6555523-B1 | Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus | CASCADE ESTATES LTD. (MU) | 2003-04-29 | — | — | US | disclosed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | disclosed |