Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114361 | 0.71 | GHSR (0.38) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL855663 | 0.67 | ALDH1A1 (0.64) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL856075 | 0.67 | CA1 (0.57) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL856237 | 0.66 | CA1 (0.70) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL222689 | 0.66 | ALDH1A1 (0.52) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL6844681 | 0.63 | ALDH1A1 (0.49) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL13159580 | 0.63 | MAPT (0.54) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL7345587 | 0.62 | HTT (0.63) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL855265 | 0.62 | CA1 (0.59) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL3058882 | 0.62 | CNR2 (0.73) | MAOAMAOBCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003035615-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-05-01 | — | — | WO | disclosed |