Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964919 | 0.93 | THRB (0.72) | THRBTHRA | |
| SCHEMBL4965136 | 0.85 | THRB (0.56) | THRBTHRA | |
| SCHEMBL23983024 | 0.82 | THRA (0.60) | THRBTHRA | |
| SCHEMBL8800915 | 0.82 | THRA (0.54) | THRBTHRA | |
| SCHEMBL18932861 | 0.82 | THRA (0.54) | THRBTHRA | |
| SCHEMBL1641051 | 0.82 | THRA (0.65) | THRBTHRA | |
| SCHEMBL4961521 | 0.82 | THRA (0.65) | THRBTHRA | |
| SCHEMBL14489297 | 0.81 | THRB (0.82) | THRBTHRA | |
| SCHEMBL8892318 | 0.81 | THRA (0.54) | THRBTHRA | |
| SCHEMBL5401923 | 0.80 | THRB (1.00) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6664291-B2 | Aromatic amidealkyl acid or ester or amide or hydroxy derivatives are useful in the treatment of obesity, overweight condition, hyperlipidemia, glucoma, cardiac arrhythmias, thyroid disease, skin disoders and diabetes | PFIZER, INC. | 2003-12-16 | — | — | US | disclosed |
| US-20010051657-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | PFIZER INC. | 2001-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051657-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | THRA, MC1R, THRB | THRB 3/4885THRA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.