Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 7/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 7/20 | 0.45 |
| ▸ | NOS2 | P35228 | 6/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5431801 | 0.92 | SLC6A4 (0.46) | SLC6A2SLC6A4NOS2CYP2D6SLC7A5 | |
| Succinic Acid SCHEMBL175860 | 0.87 | SLC6A9 (0.43) | SLC6A4CYP2D6 | |
| Oxalic Acid SCHEMBL7310725 | 0.82 | SLC6A2 (0.50) | SLC6A2SLC6A4NOS2CYP2D6SLC6A3 | |
| SCHEMBL5403775 | 0.75 | SLC6A4 (0.54) | SLC6A2SLC6A4NOS2CYP2D6SLC7A5 | |
| Oxalic Acid SCHEMBL7317717 | 0.72 | SLC6A2 (0.60) | SLC6A2SLC6A4NOS2CYP2D6SLC7A5 | |
| SCHEMBL7052799 | 0.70 | SLC6A2 (0.56) | SLC6A2SLC6A4NOS2CYP2D6SLC6A3 | |
| SCHEMBL5397001 | 0.69 | SLC6A2 (0.59) | SLC6A2SLC6A4NOS2CYP2D6SLC7A5 | |
| Oxalic Acid SCHEMBL7317056 | 0.69 | SLC6A4 (0.62) | SLC6A2SLC6A4NOS2CYP2D6SLC7A5 | |
| Oxalic Acid SCHEMBL7311161 | 0.68 | SLC6A2 (0.59) | SLC6A2SLC6A4NOS2CYP2D6SLC6A3 | |
| Oxalic Acid SCHEMBL7409520 | 0.68 | SLC6A4 (0.62) | SLC6A2SLC6A4NOS2CYP2D6SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425002-A1 | ARYLOXYPROPYLAMINES AS CHEMOSENSITIZING AGENTS IN THE TREATMENT OF CANCER | Ramot at Tel Aviv University Ltd. (IL) | 2004-06-09 | — | — | EP | claimed |
| WO-2003022258-A1 | ARYLOXYPROPYLAMINES AS CHEMOSENSITIZING AGENT IN THE TREATMENT OF CANCER | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2003-03-20 | — | — | WO | claimed |
| US-4313896-A | ANTIDEPRESSANTS, PSYCHOTROPIC AGENTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |