Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 4/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7783692 | 0.91 | HDAC6 (0.37) | TAS2R14BUB1HDAC6 | |
| SCHEMBL7120943 | 0.91 | CXCR3 (0.34) | NAMPTCXCR3TAS2R14HDAC3HDAC1 | |
| SCHEMBL7123741 | 0.89 | NAMPT (0.38) | NAMPTCXCR3BUB1MAP2K1JAK2 | |
| SCHEMBL7785868 | 0.87 | CXCR3 (0.34) | CXCR3BUB1HDAC3HDAC8HDAC6 | |
| SCHEMBL7125539 | 0.81 | MEN1 (0.45) | HDAC6MAP2K1CA2 | |
| SCHEMBL7117133 | 0.80 | HDAC6 (0.35) | NAMPTBUB1HDAC3HDAC8HDAC6 | |
| SCHEMBL6266223 | 0.80 | MEN1 (0.45) | NAMPTCXCR3TAS2R14HDAC3HDAC1 | |
| SCHEMBL7454190 | 0.79 | MEN1 (0.44) | HDAC6MAP2K1CA2 | |
| SCHEMBL7464207 | 0.77 | CCR6 (0.34) | CXCR3BUB1GAAMAP2K1 | |
| SCHEMBL7118585 | 0.77 | MEN1 (0.44) | CXCR3HDAC3HDAC8HDAC6MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |