Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | BUB1 | O43683 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7122977 | 0.91 | NAMPT (0.35) | HDAC6BUB1TAS2R14 | |
| SCHEMBL7125539 | 0.89 | MEN1 (0.45) | HDAC6MEN1KMT2ATDP1 | |
| SCHEMBL7117133 | 0.89 | HDAC6 (0.35) | HDAC6BUB1MEN1KMT2ATDP1 | |
| SCHEMBL7785868 | 0.88 | CXCR3 (0.34) | HDAC6BUB1MEN1KMT2ATDP1 | |
| SCHEMBL7454190 | 0.87 | MEN1 (0.44) | HDAC6MEN1KMT2ATDP1 | |
| SCHEMBL7115296 | 0.84 | JAK2 (0.38) | BUB1 | |
| SCHEMBL7112501 | 0.83 | BUB1 (0.32) | BUB1 | |
| SCHEMBL7120943 | 0.83 | CXCR3 (0.34) | HDAC6TAS2R14 | |
| SCHEMBL7123660 | 0.83 | MEN1 (0.45) | HDAC6MEN1KMT2ATDP1 | |
| SCHEMBL7123741 | 0.80 | NAMPT (0.38) | BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144371-A1 | BENZENESULPHONAMIDE DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | claimed |
| WO-2000042003-A1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |
| EP-1144371-A1 | BENZENESULPHONAMIDE DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000042003-A1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |