Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653946 | 0.75 | KDM4E (0.43) | KDM4ENOS3NOS1NOS2IDO1 | |
| SCHEMBL11985899 | 0.75 | POLB (0.35) | NOS3NOS1NOS2POLBAPOBEC3G | |
| SCHEMBL8344113 | 0.75 | KDM4E (0.54) | KDM4ENOS3NOS1NOS2IDO1 | |
| SCHEMBL26694656 | 0.73 | KDM4E (0.42) | KDM4ENOS3NOS1NOS2IDO1 | |
| SCHEMBL22030731 | 0.71 | NOS3 (0.39) | KDM4ENOS3NOS1NOS2IDO1 | |
| SCHEMBL14108670 | 0.68 | — | — | |
| SCHEMBL31330045 | 0.68 | KDM4E (0.38) | KDM4ENOS3NOS1NOS2IDO1 | |
| SCHEMBL31330044 | 0.68 | KDM4E (0.38) | KDM4ENOS3NOS1NOS2IDO1 | |
| SCHEMBL23181492 | 0.68 | NOS3 (0.37) | KDM4ENOS3NOS1NOS2ADORA2A | |
| SCHEMBL27062050 | 0.67 | KDM4E (0.37) | KDM4ENOS3NOS1NOS2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686199-B9 | FUSED RING DERIVATIVE AS A2A RECEPTOR INHIBITOR | CSTONE PHARMACEUTICALS SUZHOU CO LTD (CN) | 2022-12-07 | — | — | EP | disclosed |
| US-8653248-B2 | 2-aminopyridine and 2-pyridone C-nucleosides | ISIS PHARMACEUTICALS, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-20030120065-A1 | 2-aminopyridine and 2-pyridone C-nucleosides | ISIS PHARMACEUTICALS, INC. | 2003-06-26 | — | — | US | disclosed |
| US-6495672-B1 | DIAGNOSIS AND SEPARATION THROUGH TRIPLEX BINDING | ISIS PHARMACEUTICALS, INC. | 2002-12-17 | — | — | US | disclosed |
| US-6447998-B1 | METHOD OF DETECTING THE PRESENCE, ABSENCE OR AMOUNT OF A PARTICULAR DNA DUPLEX IN A SAMPLE SUSPECTED OF CONTAINING DNA COMPRISING CONTACTING THE SAMPLE WITH AN OLIGOMER OF UNDER CONDITIONS WHEREIN A TRIPLE HELIX IS FORMED BETWEEN THE | ISIS PHARMACEUTICALS, INC. | 2002-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030120065-A1 | 2-aminopyridine and 2-pyridone C-nucleosides | NT5C2, NT5C3B, TYMP | KDM4E 2762/4885NOS3 4306/4885NOS1 4336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.