Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL7121785 | 0.89 | RGS12 (0.36) | RGS12TSHR | |
| Hydrazine SCHEMBL7117203 | 0.87 | MEN1 (0.36) | RGS12TSHRMEN1KDM4ATDP2 | |
| SCHEMBL131785 | 0.87 | MEN1 (0.38) | RGS12TSHRMEN1KDM4ATDP2 | |
| Potassium SCHEMBL9326178 | 0.85 | MEN1 (0.37) | TSHRMEN1KDM4ATDP2KMT2A | |
| Ammonia Solution, Strong SCHEMBL7125861 | 0.85 | MEN1 (0.37) | TSHRMEN1KDM4ATDP2KMT2A | |
| Water SCHEMBL6481817 | 0.85 | MEN1 (0.37) | TSHRMEN1KDM4ATDP2KMT2A | |
| Ammonia Solution, Strong SCHEMBL7125864 | 0.85 | MEN1 (0.37) | TSHRMEN1KDM4ATDP2KMT2A | |
| SCHEMBL7117332 | 0.80 | — | — | |
| SCHEMBL7117331 | 0.78 | RGS12 (0.30) | RGS12TSHR | |
| SCHEMBL28100876 | 0.70 | ALDH1A1 (0.39) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589375-B2 | Using basic copper nitrate as oxidizer | TALLEY DEFENSE SYSTEMS, INC. | 2003-07-08 | — | — | US | claimed |
| US-20030094225-A1 | LOW SOLIDS GAS GENERANT HAVING A LOW FLAME TEMPERATURE | TALLY DEFENSE SYSTEMS, INC. | 2003-05-22 | — | — | US | claimed |
| US-6589375-B2 | Using basic copper nitrate as oxidizer | TALLEY DEFENSE SYSTEMS, INC. | 2003-07-08 | — | — | US | disclosed |
| US-6589375-B2 | Using basic copper nitrate as oxidizer | TALLEY DEFENSE SYSTEMS, INC. | 2003-07-08 | — | — | US | disclosed |
| US-20030094225-A1 | LOW SOLIDS GAS GENERANT HAVING A LOW FLAME TEMPERATURE | TALLY DEFENSE SYSTEMS, INC. | 2003-05-22 | — | — | US | disclosed |
| US-20030094225-A1 | LOW SOLIDS GAS GENERANT HAVING A LOW FLAME TEMPERATURE | TALLY DEFENSE SYSTEMS, INC. | 2003-05-22 | — | — | US | disclosed |