Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GABRP | O00591 | 7/20 | 0.47 |
| ▸ | GABRD | O14764 | 7/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.47 |
| ▸ | GABRE | P78334 | 7/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2891190 | 0.87 | GABRA1 (0.46) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9901416 | 0.84 | CYP1A2 (0.51) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5649405 | 0.84 | KMT2A (0.44) | TP53ACACBLMNAALDH1A1NPC1 | |
| SCHEMBL165125 | 0.83 | MAPK1 (0.57) | TP53ACACBLMNAALDH1A1KDM4E | |
| SCHEMBL27039527 | 0.82 | ACACB (0.37) | MAPTTP53ACACBLMNAKMT2A | |
| SCHEMBL27812384 | 0.81 | ACACB (0.44) | MAPTACACBALDH1A1KDM4EKMT2A | |
| SCHEMBL711104 | 0.79 | KMT2A (0.55) | ACACBALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL5649401 | 0.79 | KMT2A (0.55) | ACACBALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL104785 | 0.79 | ACACB (0.47) | TP53ACACBLMNAALDH1A1KMT2A | |
| SCHEMBL2411829 | 0.78 | GABRA1 (0.49) | CYP1A2GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2236494-B1 | SULFONYL SUBSTITUTED 6-MEMBERED RING DERIVATIVE | MSD KK (JP) | 2016-08-31 | — | — | EP | disclosed |
| EP-2261210-B1 | 3-SUBSTITUTED SULFONYL PIPERAZINE DERIVATIVE | MSD KK (JP) | 2014-10-22 | — | — | EP | disclosed |
| US-8367698-B2 | 3-substituted sulfonyl piperidine derivative | MSD K.K. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-20120232109-A1 | 3-SUBSTITUTED SULFONYL PIPERIDINE DERIVATIVE | NAGASE TSUYOSHI (JP) | 2012-09-13 | — | — | US | disclosed |
| US-8188280-B2 | 3-substituted sulfonyl piperidine derivative | MSD K.K. (JP) | 2012-05-29 | — | — | US | disclosed |
| US-8124807-B2 | Sulfonyl-substituted 6-membered ring derivative | MSD K.K. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20100331360-A1 | 3-SUBSTITUTED SULFONYL PIPERIDINE DERIVATIVE | MSD K.K. (JP) | 2010-12-30 | — | — | US | disclosed |
| EP-2261210-A1 | 3-SUBSTITUTED SULFONYL PIPERAZINE DERIVATIVE | Banyu Pharmaceutical Co., Ltd. (JP) | 2010-12-15 | — | — | EP | disclosed |
| EP-2236494-A1 | SULFONYL SUBSTITUTED 6-MEMBERED RING DERIVATIVE | Banyu Pharmaceutical Co., Ltd. (JP) | 2010-10-06 | — | — | EP | disclosed |
| US-20100249147-A1 | SULFONYL-SUBSTITUTED 6-MEMBERED RING DERIVATIVE | MSD K.K. (JP) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249147-A1 | SULFONYL-SUBSTITUTED 6-MEMBERED RING DERIVATIVE | CHRM2, CHRM3, CHRM1 | CYP1A2 168/4885GABRP 2929/4885GABRD 3492/4885 |
| US-20100331360-A1 | 3-SUBSTITUTED SULFONYL PIPERIDINE DERIVATIVE | H1-3, H1-0, H1-2 | CYP1A2 880/4885GABRP 3539/4885GABRD 3972/4885 |
| US-20120232109-A1 | 3-SUBSTITUTED SULFONYL PIPERIDINE DERIVATIVE | H1-3, H1-0, H1-2 | CYP1A2 880/4885GABRP 3539/4885GABRD 3972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.