SCHEMBL7124777

SCHEMBL7124777

O=C(CS)Nc1ccc(Nc2ccccc2)cc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.68
GAA P10253 3/20 0.68
HPGD P15428 4/20 0.64
ALDH1A1 P00352 1/20 0.64
CASP3 P42574 1/20 0.62
SENP7 Q9BQF6 1/20 0.62
LMNA P02545 1/20 0.62
RAB9A P51151 1/20 0.62
ALOX12 P18054 1/20 0.62
MAPK1 P28482 1/20 0.62
HTT P42858 1/20 0.62
POLB P06746 2/20 0.61
MEN1 O00255 1/20 0.61
KMT2A Q03164 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
GFER P55789 1/20 0.58
HDAC3 O15379 3/20 0.57
HDAC4 P56524 3/20 0.57
HDAC1 Q13547 3/20 0.57
HDAC7 Q8WUI4 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL253778 0.92 HDAC1 (0.65) MAPTPOLBMEN1KMT2AL3MBTL1
SCHEMBL4279654 0.90 HDAC1 (0.62) MAPTPOLBMEN1KMT2AL3MBTL1
Methane SCHEMBL7236825 0.90 HDAC1 (0.62) MAPTPOLBMEN1KMT2AL3MBTL1
Carbamic Acid SCHEMBL31418353 0.86 KDM1A (0.59) MAPTPOLBMEN1KMT2AL3MBTL1
SCHEMBL1509976 0.85 MEN1 (0.64) MAPTPOLBMEN1KMT2AL3MBTL1
SCHEMBL9579761 0.85 MAPT (0.70) MAPTGAAHPGDALDH1A1CASP3
SCHEMBL12112926 0.84 MAPT (0.79) MAPTGAAHPGDALDH1A1CASP3
SCHEMBL5543655 0.82 MAPT (0.70) MAPTGAAHPGDALDH1A1CASP3
SCHEMBL7934492 0.81 SLC1A3 (0.60) MAPTLMNAHTTPOLBMEN1
SCHEMBL9817405 0.81 FABP4 (0.51) MAPTGAAPOLBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1346970-A2 Energetic materials containing an antioxidant SNPE (FR) 2003-09-24 EP claimed
US-5247027-A Age-resisting polymers comprised of segmetric units which are derived from N-(4-anilino-phenyl) -α-mercaptoacetamide or N-(4-anilino phenyl)- β-mercaptopropionamide THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-09-21 US claimed
US-4946905-A REACTING WITH A POLYMERIC SUBSTRATE IN PRESENCE OF A FREE RADICAL CATALYST THE GOODYEAR TIRE & RUBBER COMPANY (US) 1990-08-07 US claimed
EP-0203879-B1 FUNCTIONALIZED MONOMERS FROM 1-(1-ISOCYANATO-1-METHYLETHYL)-3 OR 4-(1-METHYLETHENYL) BENZENE THE GOODYEAR TIRE & RUBBER COMPANY (US) 1990-05-02 EP claimed
EP-0136250-B1 A PROCESS FOR PREPARATION OF MODIFIED POLYMERS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1989-01-18 EP claimed
CN-86103465-B PREPARATION OF FUNCTIONALIZED MONOMER FROM 1-(1-ISOCYANATO-1-METHYLETHYL)-3 4-(1-METHYLETHENYL) BENZENE 1988-12-21 CN claimed
EP-0120801-B1 A PROCESS FOR THE PREPARATION OF HIGH MOLECULAR WEIGHT POLYMERIC ANTIDEGRADANTS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1988-08-10 EP claimed
US-4760181-A N-(4-Anilino-phenyl)-beta-mercaptopropionamide and N-(4-anilino-phenyl)-alpha-mercaptoacetamide THE GOODYEAR TIRE & RUBBER COMPANY (US) 1988-07-26 US claimed
EP-0203879-A2 Functionalized monomers from 1-(1-isocyanato-1-methylethyl)-3 or 4-(1-methylethenyl) benzene THE GOODYEAR TIRE & RUBBER COMPANY (US) 1986-12-03 EP claimed
CN-86103465-A Prepare functionalized monomer's method by 1-(1-isocyanato-1 methylethyl)-3-(1-methyl ethylene) benzene or 1-(1-isocyanato-1-methylethyl)-4-(1-methyl ethylene) benzene 1986-12-03 CN claimed
US-4604439-A STABILIZERS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1986-08-05 US claimed
EP-0155221-A2 A process for the preparation of functionalized monomers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1985-09-18 EP claimed
EP-0136250-A2 A process for preparation of modified polymers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1985-04-03 EP claimed
US-4481337-A BONDING OXIDATION ANTIDEGRADANT THE GOODYEAR TIRE & RUBBER COMPANY (US) 1984-11-06 US claimed
US-11053326-B2 Oxidation resistant natural rubber and a method for its production COOPER TIRE AND RUBBER COMPANY (US) 2021-07-06 US disclosed
US-11053326-B2 Oxidation resistant natural rubber and a method for its production COOPER TIRE AND RUBBER COMPANY (US) 2021-07-06 US disclosed
US-20170247477-A1 OXIDATION RESISTANT NATURAL RUBBER AND A METHOD FOR ITS PRODUCTION GOODYEAR TIRE & RUBBER COMPANY, THE 2017-08-31 US disclosed
EP-0155221-A2 A process for the preparation of functionalized monomers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1985-09-18 EP disclosed
US-4520156-A Scorch inhibitors for carboxylated rubbers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1985-05-28 US disclosed
US-3975414-A N,N-bis(4-anilinophenyl)-4,7-dithia-5-methyldecanediamide and related compounds useful as polymer stabilizers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1976-08-17 US disclosed