Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HMGCR | P04035 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117955 | 0.90 | GAA (0.43) | MEN1KMT2AGAARAF1MAP2K1 | |
| SCHEMBL8767353 | 0.86 | MEN1 (0.49) | MEN1KMT2AGAARAF1MAP2K1 | |
| SCHEMBL8766494 | 0.85 | HMGCR (0.44) | MEN1KMT2AGAAALDH1A1HMGCR | |
| SCHEMBL7119208 | 0.82 | HMGCR (0.43) | MEN1KMT2AGAARAF1MAP2K1 | |
| SCHEMBL8766155 | 0.81 | HMGCR (0.42) | MEN1KMT2AGAARAF1MAP2K1 | |
| SCHEMBL7125857 | 0.81 | HMGCR (0.41) | MEN1KMT2AGAAHMGCRNR1I2 | |
| SCHEMBL8766578 | 0.81 | HMGCR (0.44) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL8766162 | 0.79 | HMGCR (0.42) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL7123134 | 0.77 | HMGCR (0.44) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL7122163 | 0.76 | NR1H4 (0.42) | MEN1KMT2AGAAALDH1A1HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | claimed |
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | claimed |
| US-5424303-A | For treating hypercholesterolemia and hyperlipidemia | SYMPHAR SA (CH) | 1995-06-13 | — | — | US | claimed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | claimed |
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | disclosed |
| US-5424303-A | For treating hypercholesterolemia and hyperlipidemia | SYMPHAR SA (CH) | 1995-06-13 | — | — | US | disclosed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | disclosed |