Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766643 | 0.85 | HMGCR (0.48) | HMGCRNR1I2MEN1KMT2AGAA | |
| SCHEMBL7126888 | 0.84 | MAPT (0.40) | MEN1KMT2AGAALMNAPOLB | |
| SCHEMBL8609257 | 0.83 | HMGCR (0.43) | HMGCRNR1I2MEN1KMT2AGAA | |
| SCHEMBL7120195 | 0.81 | HMGCR (0.43) | HMGCRNR1I2MEN1KMT2AGAA | |
| SCHEMBL7125849 | 0.81 | MEN1 (0.45) | HMGCRNR1I2MEN1KMT2AGAA | |
| SCHEMBL7117955 | 0.81 | GAA (0.43) | HMGCRNR1I2MEN1KMT2AGAA | |
| SCHEMBL8766983 | 0.80 | HMGCR (0.45) | HMGCRNR1I2MEN1KMT2AGAA | |
| SCHEMBL8766583 | 0.80 | HMGCR (0.43) | HMGCRNR1I2MEN1KMT2AGAA | |
| SCHEMBL8767341 | 0.79 | HMGCR (0.43) | HMGCRNR1I2MEN1KMT2AGAA | |
| SCHEMBL8766713 | 0.79 | HMGCR (0.44) | HMGCRNR1I2MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | claimed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | claimed |
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | disclosed |