Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.35 |
| ▸ | CASR | P41180 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.30 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.30 |
| ▸ | STK17B | O94768 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7123648 | 0.81 | GRM5 (0.41) | MCHR1NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL4707651 | 0.81 | KDM4E (0.32) | MCHR1NPC1RAB9AKMT2A | |
| SCHEMBL7123672 | 0.78 | MCHR1 (0.41) | MCHR1TYK2RAB9AJAK2SRC | |
| SCHEMBL5242363 | 0.78 | NPC1 (0.42) | MCHR1NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL5241545 | 0.77 | MCHR1 (0.31) | MCHR1 | |
| SCHEMBL7118397 | 0.75 | ALDH1A1 (0.43) | TYK2NPC1RAB9AJAK2 | |
| SCHEMBL5241630 | 0.75 | MCHR1 (0.36) | MCHR1TYK2NPC1RAB9AJAK2 | |
| SCHEMBL5241092 | 0.75 | MCHR1 (0.43) | MCHR1SRCIRAK4 | |
| SCHEMBL5243357 | 0.74 | KDM4E (0.50) | MCHR1NPC1RAB9A | |
| SCHEMBL7127531 | 0.73 | MCHR1 (0.31) | MCHR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030162795-A1 | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents | PFIZER INC. | 2003-08-28 | — | — | US | disclosed |
| US-6492383-B1 | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents | PFIZER INC. | 2002-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162795-A1 | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents | TYMP, DPYD, HPRT1 | MCHR1 3278/4885CASR 3824/4885RXRA 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.