Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.43 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP21 | Q9UK80 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882301 | 0.86 | MEN1 (0.49) | KMT2ALMNAMEN1FKBP4ELANE | |
| SCHEMBL7277525 | 0.84 | TACR1 (0.43) | KMT2ALMNAMEN1MAPTFKBP4 | |
| SCHEMBL8001618 | 0.83 | LMNA (0.47) | KMT2ALMNAFKBP4ELANETACR1 | |
| SCHEMBL1295583 | 0.82 | PREP (0.54) | LMNAFKBP4ELANETACR1KCNH2 | |
| SCHEMBL8010107 | 0.81 | FKBP4 (0.46) | KMT2ALMNAMEN1MAPTFKBP4 | |
| SCHEMBL5850980 | 0.79 | FKBP4 (0.48) | KMT2AMEN1FKBP4TACR1 | |
| SCHEMBL11431771 | 0.78 | PREP (0.57) | LMNAELANETACR1KCNH2KDM4E | |
| SCHEMBL27824844 | 0.78 | LMNA (0.48) | KMT2ALMNAMEN1TACR1NPC1 | |
| SCHEMBL1296384 | 0.78 | LMNA (0.48) | KMT2ALMNAMEN1TACR1NPC1 | |
| SCHEMBL6523783 | 0.78 | CMA1 (0.48) | KMT2AMEN1ELANENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0678121-B1 | METHODS AND REAGENTS FOR INHIBITING FURIN ENDOPROTEASE | OREGON STATE (US) | 2003-06-25 | — | — | EP | disclosed |
| US-6022855-A | NOVEL VARIANTS OF THE NATURALLY-OCCURRING PROTEASE INHIBITOR, ALPHA1-ANTITRYPSIN AND DERIVED PEPTIDES COMPRISING A SEQUENCE OF-ARG-XAA-XAA-ARG-; VIRICIDES; BACTERICIDES; BLOCKING OF ENDOPROTEOLYTIC ACTIVATION OF A BACTERIAL TOXIN | OREGAN HEALTH SCIENCES UNIVERSITY (US) | 2000-02-08 | — | — | US | disclosed |