Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP4 | Q02790 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | USP21 | Q9UK80 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277525 | 0.94 | TACR1 (0.43) | FKBP4TACR1LMNANAMPTMMP2 | |
| SCHEMBL3396899 | 0.90 | ELANE (0.48) | FKBP4TACR1LMNANAMPTMMP2 | |
| SCHEMBL1257864 | 0.90 | LMNA (0.53) | TACR1LMNANAMPTMMP2MMP9 | |
| SCHEMBL8001618 | 0.89 | LMNA (0.47) | FKBP4TACR1LMNANAMPTMMP2 | |
| SCHEMBL5501048 | 0.88 | TACR1 (0.47) | FKBP4TACR1LMNAMMP2TRPV1 | |
| SCHEMBL27824844 | 0.87 | LMNA (0.48) | TACR1LMNANAMPTMMP2MMP9 | |
| SCHEMBL1296384 | 0.87 | LMNA (0.48) | TACR1LMNANAMPTMMP2MMP9 | |
| SCHEMBL8691338 | 0.86 | ELANE (0.46) | FKBP4TACR1LMNANAMPTMMP2 | |
| SCHEMBL3667052 | 0.86 | FKBP4 (0.58) | FKBP4TACR1KMT2A | |
| SCHEMBL5501196 | 0.85 | TACR1 (0.44) | FKBP4TACR1LMNAMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127144-A | PRODUCING HETEROLOGOUS PROTEINS BY INCUBATING STREPTOMYCES CELL TRANSFORMED WITH NUCLEIC ACID EXPRESSION CONSTRUCT IN PRESENCE OF PEPTIDE-SUSBSTITUTED CHLOROMETHYLKETONE AMINOPEPTIDASE INHIBITOR HAVING DEFINED STRUCTURE | CANGENE CORPORATION (CA) | 2000-10-03 | — | — | US | disclosed |
| EP-0731841-A1 | PROTEASES FROM STREPTOMYCES AND USE THEREOF IN PROTEIN EXPRESSION SYSTEMS | Cangene Corporation (CA) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995017512-A2 | PROTEASES FROM STREPTOMYCES AND USE THEREOF IN PROTEIN EXPRESSION SYSTEMS | CANGENE CORPORATION (CA) | 1995-06-29 | — | — | WO | disclosed |
| US-5364848-A | Elastase inhibitors | MERCK & CO., INC. (US) | 1994-11-15 | — | — | US | disclosed |