Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 6/20 | 0.41 |
| ▸ | UBE2M | P61081 | 2/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL447181 | 0.92 | HRH3 (0.47) | HRH3CCR2UBE2MDCUN1D1HTR2A | |
| SCHEMBL445308 | 0.81 | EPHX2 (0.51) | ALDH1A1TRPV4SIGMAR1 | |
| SCHEMBL428036 | 0.73 | SIGMAR1 (0.51) | HRH3CCR2KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL448430 | 0.72 | MEN1 (0.49) | CCR2UBE2MDCUN1D1KDM4EALDH1A1 | |
| SCHEMBL444935 | 0.71 | MAPT (0.50) | ALDH1A1TRPV4 | |
| SCHEMBL21974820 | 0.71 | DDR2 (0.56) | KDM4EALDH1A1TDP1KDM4C | |
| SCHEMBL7111066 | 0.71 | HRH3 (0.47) | HRH3CCR2KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL9886158 | 0.71 | MAPT (0.47) | ALDH1A1 | |
| SCHEMBL22705221 | 0.70 | KDM4E (0.44) | HRH3KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL10751967 | 0.70 | LMNA (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |