SCHEMBL7126787

SCHEMBL7126787

CC(C)(C)OC(=O)CN1CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)N2CCN(C(=O)CN3CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC3)c3ccccc32)CCN(CC(=O)OC(C)(C)C)CC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.49
CHRM4 P08173 1/20 0.49
CHRM1 P11229 1/20 0.49
CHRM3 P20309 1/20 0.49
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 2/20 0.44
POLB P06746 1/20 0.44
PKM P14618 1/20 0.44
DRD2 P14416 6/20 0.43
DRD4 P21917 5/20 0.43
KMT2A Q03164 4/20 0.43
MEN1 O00255 2/20 0.43
GAA P10253 1/20 0.43
ADRA1D P25100 1/20 0.43
ADRA1A P35348 1/20 0.43
ADRA1B P35368 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
HDAC1 Q13547 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
NR1I3 Q14994 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24495626 0.81 ALDH1A1 (0.55) ALDH1A1KDM4EPOLBDRD2DRD4
SCHEMBL5793723 0.78 DRD2 (0.65) ALDH1A1KDM4EDRD2DRD4KMT2A
SCHEMBL27147241 0.78 PLA2G10 (0.41) CHRM2CHRM4CHRM1CHRM3ALDH1A1
SCHEMBL3799622 0.78 PLA2G10 (0.41) CHRM2CHRM4CHRM1CHRM3ALDH1A1
SCHEMBL3470166 0.78 PLA2G10 (0.41) CHRM2CHRM4CHRM1CHRM3ALDH1A1
SCHEMBL7132319 0.77 ALDH1A1 (0.55) ALDH1A1KDM4EPOLBPKMDRD2
SCHEMBL10063608 0.77 ALDH1A1 (0.57) ALDH1A1KMT2AMEN1MAPT
SCHEMBL20957025 0.76 CHRM2 (0.60) CHRM2CHRM4CHRM1CHRM3ALDH1A1
SCHEMBL7132345 0.76 GAA (0.50) CHRM2CHRM4CHRM1CHRM3ALDH1A1
SCHEMBL12004770 0.75 ALDH1A1 (0.49) CHRM2CHRM4CHRM1CHRM3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0722442-B1 POLYAZACYCLOALKANES AS DICHELANTS NYCOMED SALUTAR INC (US) 2003-01-15 EP disclosed
US-5972307-A ADMINISTERING TO HUMAN OR ANIMAL BODY AN EFFECTIVE AMOUNT OF A DIAGNOSTIC AGENT COMPRISES A METAL CHELATE OF A COMPOUND HAVING TWO MACROCYCLIC CHELANT GROUPS LINKED BY A BRIDGE CONTAINING ESTER OR AMIDE BOND NYCOMED SALUTAR, INC. (US) 1999-10-26 US disclosed
US-5650133-A CHELATING AGENTS USEFUL IN DIAGNOSTIC AND THERAPEUTIC COMPOSITIONS NYCOMED SALUTAR (US) 1997-07-22 US disclosed
WO-1995009848-A2 POLYAZACYCLOALKANES AS DICHELANTS NYCOMED SALUTAR, INC. (US) 1995-04-13 WO disclosed