Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 11/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120572 | 0.85 | EPHX2 (0.49) | EPHX2MMP2MMP7MMP9MMP13 | |
| SCHEMBL7122570 | 0.84 | EZH2 (0.55) | EZH2MAPK14PTGDR2LPAR1LPAR5 | |
| SCHEMBL7125236 | 0.84 | PARP10 (0.47) | EZH2LPAR1LPAR5MMP2MMP7 | |
| SCHEMBL7123411 | 0.84 | MMP2 (0.43) | EZH2MMP2MMP7MMP9MMP13 | |
| SCHEMBL7117157 | 0.84 | EZH2 (0.56) | EZH2MMP2MMP7MMP9MMP13 | |
| SCHEMBL7124896 | 0.84 | MMP2 (0.57) | EZH2KCNH2MMP2MMP7MMP9 | |
| SCHEMBL6306261 | 0.82 | EZH2 (0.58) | EZH2MAPK14KCNH2CYP3A4PTGDR2 | |
| SCHEMBL7123878 | 0.82 | CTNNB1 (0.46) | EZH2MMP2MMP7MMP9MMP13 | |
| SCHEMBL7125189 | 0.82 | EZH2 (0.42) | EZH2MMP2MMP7MMP9MMP13 | |
| SCHEMBL7114399 | 0.82 | EZH2 (0.44) | EZH2MMP2MMP7MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030069296-A1 | Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-04-10 | — | — | US | claimed |
| US-20030069296-A1 | Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069296-A1 | Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease | CYP7B1, UGT2B7, CYP1B1 | EZH2 462/4885MAPK14 3088/4885KCNH2 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.