Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 7/20 | 0.49 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115999 | 0.92 | ADRB2 (0.60) | ADRB2KMT2ATOP2ATOP2BSTAT3 | |
| SCHEMBL10413931 | 0.90 | ADRB2 (0.52) | ADRB2TOP2ATOP2BKCNH2KDM4E | |
| SCHEMBL2844967 | 0.89 | ADRB2 (0.68) | ADRB2KMT2ATOP2ATOP2BSTAT3 | |
| SCHEMBL29492858 | 0.89 | ADRB2 (0.68) | ADRB2KMT2ATOP2ATOP2BSTAT3 | |
| SCHEMBL10627001 | 0.87 | ADRB2 (0.66) | ADRB2KMT2ATOP2ATOP2BSTAT3 | |
| SCHEMBL7599453 | 0.86 | ADRB2 (0.65) | ADRB2KMT2ATOP2ATOP2BSTAT3 | |
| SCHEMBL9693055 | 0.86 | ADRB2 (0.65) | ADRB2KMT2ATOP2ATOP2BSTAT3 | |
| SCHEMBL114733 | 0.86 | ADRB2 (0.60) | ADRB2KMT2ATOP2ATOP2BSTAT3 | |
| SCHEMBL5704396 | 0.85 | ADRB2 (0.64) | ADRB2KMT2ATOP2ATOP2BSTAT3 | |
| SCHEMBL143605 | 0.85 | ADRB2 (0.64) | ADRB2KMT2ATOP2ATOP2BSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-4945160-A | Preparation of certain 7-substituted quinolones | WARNER-LAMBERT COMPANY (US) | 1990-07-31 | — | — | US | disclosed |