Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | FGR | P09769 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7128004 | 0.85 | KDR (0.41) | PDGFRBABL1LCKLYNMET | |
| SCHEMBL7847654 | 0.80 | KDR (0.44) | AURKAMETKDRTEKAURKB | |
| SCHEMBL7128426 | 0.79 | PDE10A (0.38) | PDGFRBPDE10A | |
| SCHEMBL5015530 | 0.78 | EGFR (0.42) | PDE10AMETKDR | |
| SCHEMBL5017339 | 0.77 | CHEK2 (0.44) | PDE10A | |
| SCHEMBL13998242 | 0.72 | EGFR (0.42) | PDE10AMETKDR | |
| SCHEMBL7848154 | 0.71 | KDR (0.43) | AURKAMETKDRTEKAURKB | |
| SCHEMBL7838003 | 0.70 | KDR (0.39) | AURKAMETKDRTEKAURKB | |
| SCHEMBL5912648 | 0.70 | ENPP1 (0.43) | PDGFRBKDR | |
| SCHEMBL7129696 | 0.69 | KDR (0.47) | PDGFRBPDE10AABL1LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309587-A1 | CINNOLINE COMPOUNDS | AstraZeneca AB (SE) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012228-A1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |