Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5912648 | 0.83 | ENPP1 (0.43) | PDGFRB | |
| SCHEMBL7127947 | 0.79 | MAP3K5 (0.35) | PDE10APDGFRB | |
| SCHEMBL7128004 | 0.78 | KDR (0.41) | CYP3A4CYP2C19PDGFRB | |
| SCHEMBL6909493 | 0.73 | HDAC6 (0.43) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL6168405 | 0.73 | CA12 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7482777 | 0.71 | KDR (0.62) | SLC6A4SLC6A3PDGFRB | |
| SCHEMBL7476474 | 0.70 | KDR (0.63) | — | |
| SCHEMBL5245231 | 0.70 | PDE10A (0.56) | PDE10ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29589019 | 0.70 | PDE10A (0.56) | PDE10ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6166429 | 0.70 | MAPT (0.48) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309587-A1 | CINNOLINE COMPOUNDS | AstraZeneca AB (SE) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012228-A1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |