Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766148 | 0.78 | HMGCR (0.46) | HMGCRNR1I2MAPTLMNAGAA | |
| SCHEMBL8766586 | 0.78 | MEN1 (0.43) | HMGCRMAPTKDM4ELMNAGAA | |
| SCHEMBL7124088 | 0.77 | HMGCR (0.47) | HMGCRNR1I2MAPTLMNAGAA | |
| SCHEMBL8011719 | 0.75 | HMGCR (0.51) | HMGCRNR1I2KDM4ELMNAGAA | |
| SCHEMBL7123134 | 0.72 | HMGCR (0.44) | HMGCRNR1I2MAPTKDM4ELMNA | |
| SCHEMBL8766484 | 0.71 | HMGCR (0.38) | HMGCRLMNAGAARECQLMEN1 | |
| SCHEMBL8766996 | 0.71 | HMGCR (0.44) | HMGCRNR1I2MAPTKDM4ELMNA | |
| SCHEMBL8766091 | 0.68 | HMGCR (0.41) | HMGCRNR1I2MAPTKDM4ELMNA | |
| SCHEMBL8766505 | 0.68 | MEN1 (0.39) | HMGCRLMNAGAARECQLMEN1 | |
| SCHEMBL9418530 | 0.67 | HMGCR (0.60) | HMGCRNR1I2MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | disclosed |