Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766484 | 0.93 | HMGCR (0.38) | HMGCRLMNAGAAMEN1KMT2A | |
| SCHEMBL8766996 | 0.91 | HMGCR (0.44) | HMGCRLMNAALDH1A1MAPTGAA | |
| SCHEMBL8766505 | 0.90 | MEN1 (0.39) | HMGCRLMNAGAAMEN1KMT2A | |
| SCHEMBL8766187 | 0.89 | HMGCR (0.46) | HMGCRLMNAGAAMEN1KMT2A | |
| SCHEMBL8766605 | 0.87 | FDPS (0.41) | LMNAGAAMEN1KMT2AFDPS | |
| SCHEMBL8766091 | 0.87 | HMGCR (0.41) | HMGCRLMNAALDH1A1MAPTGAA | |
| SCHEMBL8766586 | 0.82 | MEN1 (0.43) | HMGCRLMNAALDH1A1MAPTGAA | |
| SCHEMBL7128247 | 0.78 | HMGCR (0.47) | HMGCRLMNAALDH1A1MAPTGAA | |
| SCHEMBL8766613 | 0.76 | HMGCR (0.49) | HMGCRMAPTGAAMEN1KMT2A | |
| SCHEMBL7119208 | 0.74 | HMGCR (0.43) | HMGCRLMNAGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | claimed |
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | disclosed |
| US-5424303-A | For treating hypercholesterolemia and hyperlipidemia | SYMPHAR SA (CH) | 1995-06-13 | — | — | US | disclosed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | disclosed |