Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767015 | 0.88 | MEN1 (0.47) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL8766148 | 0.82 | HMGCR (0.46) | MEN1KMT2AGAAHMGCRALDH1A1 | |
| SCHEMBL8014329 | 0.79 | MEN1 (0.51) | MEN1KMT2AGAAHMGCRALDH1A1 | |
| SCHEMBL7128247 | 0.78 | HMGCR (0.47) | MEN1KMT2AGAAHMGCRKDM4E | |
| SCHEMBL8766484 | 0.75 | HMGCR (0.38) | MEN1KMT2AGAAHMGCRRECQL | |
| SCHEMBL8015604 | 0.75 | GAA (0.48) | MEN1KMT2AGAAHMGCRALDH1A1 | |
| SCHEMBL7125849 | 0.75 | MEN1 (0.45) | MEN1KMT2AGAAHMGCRKDM4E | |
| SCHEMBL8766996 | 0.73 | HMGCR (0.44) | MEN1KMT2AGAAHMGCRKDM4E | |
| SCHEMBL8766505 | 0.72 | MEN1 (0.39) | MEN1KMT2AGAAHMGCRRECQL | |
| SCHEMBL8766187 | 0.71 | HMGCR (0.46) | MEN1KMT2AGAAHMGCRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| US-5424303-A | For treating hypercholesterolemia and hyperlipidemia | SYMPHAR SA (CH) | 1995-06-13 | — | — | US | claimed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | claimed |