Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.41 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.39 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125756 | 0.89 | LMNA (0.46) | LMNAPIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL7128889 | 0.85 | LMNA (0.37) | LMNATDP1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2998174 | 0.80 | MAP2K2 (0.52) | LMNAPIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL4141613 | 0.80 | LMNA (0.52) | LMNAPIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL1431428 | 0.79 | LMNA (0.63) | LMNAPIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL3003412 | 0.77 | LMNA (0.46) | LMNAPIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL7120371 | 0.77 | LMNA (0.52) | LMNAPIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL7128946 | 0.77 | LMNA (0.52) | LMNAPIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL7124395 | 0.76 | LMNA (0.51) | LMNAPIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL7128069 | 0.76 | PIM1 (0.56) | LMNAPIM1IRAK1CAMK2BCAMK2G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |