Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.56 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.56 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475280 | 0.86 | P2RX3 (0.56) | PIM1IRAK1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL5101006 | 0.86 | NR4A2 (0.59) | PIM1IRAK1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL7122619 | 0.83 | CAPN1 (0.52) | ALDH1A1LMNAKDM4EHPGDNR4A2 | |
| SCHEMBL30417213 | 0.83 | KMT2A (0.59) | PIM1IRAK1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL10472497 | 0.83 | KMT2A (0.59) | PIM1IRAK1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL2998174 | 0.82 | MAP2K2 (0.52) | PIM1IRAK1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL1431428 | 0.81 | LMNA (0.63) | PIM1IRAK1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL31513796 | 0.79 | NPC1 (0.60) | PIM1IRAK1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL10963972 | 0.79 | ALDH1A1 (0.52) | PIM1IRAK1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL7125756 | 0.79 | LMNA (0.46) | PIM1IRAK1CAMK2BCAMK2GCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |