Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | DDX3X | O00571 | 1/20 | 0.51 |
| ▸ | TOP1 | P11387 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660580 | 0.86 | MEN1 (0.62) | SMN1; SMN2MAPTALDH1A1TOP1TOP2A | |
| SCHEMBL4319185 | 0.84 | SNCA (0.65) | PTGS1SMN1; SMN2MAPTALDH1A1TOP1 | |
| SCHEMBL9417262 | 0.83 | MEN1 (0.62) | SMN1; SMN2ALDH1A1TOP1TOP2ATOP2B | |
| SCHEMBL26737633 | 0.82 | DDX3X (0.69) | PTGS1SMN1; SMN2MAPTALDH1A1DDX3X | |
| SCHEMBL7301884 | 0.81 | PTGS1 (0.74) | PTGS1SMN1; SMN2MAPTALDH1A1DDX3X | |
| SCHEMBL4652364 | 0.81 | MEN1 (0.56) | SMN1; SMN2MAPTALDH1A1TOP1TOP2A | |
| SCHEMBL10316419 | 0.81 | TOP1 (0.78) | PTGS1SMN1; SMN2MAPTALDH1A1DDX3X | |
| SCHEMBL9417400 | 0.80 | NR1H4 (0.58) | MAPTALDH1A1TOP1TOP2ATOP2B | |
| SCHEMBL9321376 | 0.79 | PTGS1 (0.61) | PTGS1SMN1; SMN2MAPTALDH1A1DDX3X | |
| SCHEMBL23997793 | 0.79 | PTGS1 (0.58) | PTGS1SMN1; SMN2MAPTALDH1A1DDX3X |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030134859-A1 | PPAR-gamma modulator | SANKYO COMPANY, LIMITED (JP) | 2003-07-17 | — | — | US | disclosed |
| EP-1277729-A1 | PPAR (GAMMA) MODULATORS | Sankyo Company, Limited (JP) | 2003-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134859-A1 | PPAR-gamma modulator | PPARG, PPARA, PPARD | PTGS1 313/4885SMN1; SMN2 3743/4885MAPT 4391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.