Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.47 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716881 | 0.88 | MAPT (0.70) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL31204910 | 0.86 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL3714863 | 0.86 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL22261288 | 0.82 | JAK3 (0.60) | KDM4EJAK3L3MBTL1RPS6KB1AKT1 | |
| SCHEMBL448276 | 0.79 | MEN1 (0.64) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL17490812 | 0.79 | ALDH1A1 (0.75) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL1233669 | 0.79 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL22731793 | 0.77 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL447482 | 0.77 | MEN1 (0.65) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL20722727 | 0.76 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |