Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 5/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27489770 | 0.92 | HTR2A (0.49) | HTR2AMTNR1AMTNR1B | |
| SCHEMBL18053268 | 0.83 | CYP2A6 (0.50) | HTR1BHTR1DSLC6A4HRH1MAPT | |
| SCHEMBL29843515 | 0.82 | CYP1A2 (0.41) | HTR1BHTR1DHTR1AHTR2AMTNR1A | |
| SCHEMBL8973802 | 0.81 | CYP1A2 (0.44) | HTR1BHTR1DSLC6A4HRH1MAPT | |
| SCHEMBL8974397 | 0.80 | HTR1B (0.56) | HTR1BHTR1DKCNA3SLC6A4HRH1 | |
| SCHEMBL29937036 | 0.80 | HTR1B (0.56) | HTR1BHTR1DKCNA3SLC6A4HRH1 | |
| SCHEMBL3819696 | 0.79 | MTNR1A (0.51) | HTR1BHTR1DHTR1AMTNR1AMAPT | |
| SCHEMBL29936898 | 0.78 | CYP1A2 (0.59) | MAPTAGXT | |
| SCHEMBL1961527 | 0.78 | CYP1A2 (0.59) | MAPTAGXT | |
| SCHEMBL15772597 | 0.77 | MTNR1A (0.49) | HTR2AMTNR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |