Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 10/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25629899 | 0.83 | CYP1A2 (0.50) | CYP1A2CYP2A6ALDH1A1MAPT | |
| SCHEMBL18053268 | 0.81 | CYP2A6 (0.50) | CYP1A2CYP2A6HTR1BHTR1DALDH1A1 | |
| SCHEMBL7129651 | 0.81 | HTR1B (0.40) | HTR1BHTR1DMAPTSLC6A4HRH1 | |
| SCHEMBL27489770 | 0.79 | HTR2A (0.49) | CYP1A2CYP2A6 | |
| SCHEMBL8974397 | 0.78 | HTR1B (0.56) | CYP1A2HTR1BHTR1DALDH1A1SLC6A4 | |
| SCHEMBL29937036 | 0.78 | HTR1B (0.56) | CYP1A2HTR1BHTR1DALDH1A1SLC6A4 | |
| SCHEMBL8399146 | 0.74 | AKT1 (0.47) | CYP1A2CYP2A6ALDH1A1GAAMAPT | |
| SCHEMBL15345486 | 0.73 | HTR1B (0.44) | CYP2A6HTR1BALDH1A1GAAMAPT | |
| SCHEMBL1050592 | 0.73 | KDM1A (0.44) | HTR1BHTR1DSLC6A4HRH1 | |
| SCHEMBL1051243 | 0.73 | KDM1A (0.44) | HTR1BHTR1DALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| CN-1027064-C | Naphthalene derivatives | EISAI CO LTD (JP) | 1994-12-21 | — | — | CN | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| CN-1043696-A | NAPHTHALENE DERIVATIVES | EISAI CO LTD (JP) | 1990-07-11 | — | — | CN | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |